王石峰，出生于江西省赣州市，2017年毕业于北京中医药大学，获博士学位，导师：乔延江教授。硕博研究生期间联合培养于中国科学院北京基因组所，研究方向为中药药性科学内涵研究，合作导师：栗世铀副研究员。博士毕业后，经学校选派进入美国科罗拉多大学博尔德分校，于分子细胞与发育生物学系开展博士后研究。主要研究方向为基于CRISPR/Cas9全基因组筛选探究膜蛋白GLUT4的细胞空间转运调控机制。以第一作者或共一作者在Science Advances，Journal of Biological Chemistry，Traffic，Journal of Ethnopharmacology等发表研究论文10篇。
主要研究方向：
1. 中药药性、中药功效、物质基础及作用机制研究。
2. 基于高通量/高内涵筛选的中药作用靶点研究。
3. 基于CRISPR/Cas9药物靶点研究。
在研课题：
1. 国家自然科学基金青年项目，丹参酮类成分调控TFEB驱动溶酶体自噬改善NAFLD胰岛素抵抗药效机制研究，项目编号：82304715，主持，在研。
2. 北京市自然科学基金创新联合项目，基于TFEB通路介导的线粒体自噬探究仙鹤草改善糖尿病肌少症活性物质及作用机制，项目编号: L256064, 主持，在研。
代表性论文
(1) Lulu Zheng, Beiyan Li, Anlei Yuan, Shijie Bi, Harrison Puscher, Chaoqun Liu, Liansheng Qiao, Yanjiang Qiao, Shifeng Wang*, Yanling Zhang*. TFEB activator tanshinone IIA and derivatives derived from Salvia miltiorrhiza Bge. Attenuate hepatic steatosis and insulin resistance. Journal of Ethnopharmacology. 2024,335:118662.
(2) Shifeng Wang, Xu Chen, Lauren Crisman, Ximing Dou, Christina S. Winborn, Chun Wan, Harrison Puscher, Qian Yin, Matthew J. Kennedy, Jingshi Shen*. Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module. Science Advances. 2023,9(8): ade2540.
(3) Bridget L. Menasche#, Eric M. Davis#, Shifeng Wang#, Yan Ouyang, Suzhao Li, Haijia Yu, Jingshi Shen*. PBRM1 and the glycosylphosphatidylinositol biosynthetic pathway promote tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes. Science Advances, 2020,6(8): eabc3243.
(4) Shifeng Wang, Yinghui Liu, Lauren Crisman, Chun Wan, Jessica Miller, Haijia Yu*, Jingshi Shen*. Genetic evidence for an inhibitory role of tomosyn in insulin‐stimulated GLUT4 exocytosis. Traffic, 2020, 21(10): 636-646.
(5) Shifeng Wang#, Lauren Crisman#, Jessica Miller, Ishara Datta, Daniel R. Gulbranson, Yuan Tian, Qian Yin, Haijia Yu, Jingshi Shen*. Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis. Journal of Biological Chemistry, 2019, 294(52): 19988-19996.
(6) Jiayu Zhang#, Shifeng Wang#, Lulu Xu, Qiao Zhang, Zhanpeng Shang, Yanling Zhang, Qinghua Wu, Shiyou Li*, Yanjing Qiao*, Multiple Perspectives of Qingkailing Injection Fraction-Single Compound in Revealing the Hepatotoxicity of Baicalin and Hyodeoxycholic Acid, Journal of Ethnopharmacology, 2018, 215: 147-155.
(7) Shifeng Wang, Yuxin Zhang, Qiao Zhang, Sha Peng, Chen Shen, Yangyang Yu, Minyu Zhang, Wei Yang, Qinghua Wu, Yanling Zhang, Shiyou Li*, Yanjiang Qiao*, Content decline of SERCA inhibitors saikosaponin a and d attenuates cardiotoxicity and hepatotoxicity of vinegar-baked Radix Bupleuri. Environmental Toxicology and Pharmacology, 2017, 52: 129-137.
(8) Shifeng Wang, Qiao Zhang, Yuxin Zhang, Cheng Shen, Zhen Wang, Qinghua Wu, Yanling Zhang, Shiyou Li*, Yanjiang Qiao*, Agrimol B suppresses adipogenesis through modulation of SIRT1-PPARγ signal pathway. Biochemical and Biophysical Research Communications, 2016, 477(3): 454-460.
(9) Shifeng Wang, Chenxi Zhai, Yanling Zhang, Yangyang Yu, Yuxin Zhang, Lianghui Ma, Shiyou Li*, Yanjiang Qiao*, Cardamonin, a novel antagonist of hTRPA1 cation channel, reveals therapeutic mechanism of pathological pain. Molecules, 2016, 21(9), pii: E1145.
(10) Shifeng Wang, Qiao Zhang, Yuxin Zhang, Yanling Zhang, Qinghua Wu, Shiyou Li*, Yanjiang Qiao*, Identification of berbamine dihydrochloride from barberry as an anti-adipogenic agent by high-content imaging assay. Journal of Traditional Chinese Medical Sciences, 2016, 3: 91-99.
联系方式：
通讯地址：北京市房山区阳光南大街北京中医药大学中药学院
邮政编码：100029
E-mail: wangshifeng@bucm.edu.cn
