张燕玲，博士，研究员，博士生导师。世界中医药学会联合会中药系统工程与科学专业委员会副会长兼副秘书长，世界中医药学会联合会网络药理学常务理事等。针对中药有效成分复杂、作用机理不明确的关键科学问题，立足于传统中医药理论，紧扣中医药现代化发展需求，整合中药学、生物学、信息学等多学科技术，构建体现中药特点的、高效快速的中药成分筛选、机理解析、中药质量评价、中药新药设计及大健康产品开发的系统方法体系和技术平台。已建立了中药网络构建、模块分析、作用机理解析技术平台，构建了含有常用500余味中药的2万余化学成分、300余靶点活性成分辨识模型、药物代谢动力学性质预测模型的数据平台，80余中药性效评价高内涵筛选细胞系，为中药药效/功效成分的快速发现、中药药效/功效作用机制解析、中药综合开发利用及大健康产品研发奠定了基础。目前，共主持课题十余项，包括国家自然科学基金面上项目3项、省部级课题4项；参加30余项科研课题，包括国家973计划、国家支撑计划、国家自然基金重点项目等课题十余项；以第一和通讯作者发表学术论文近150篇，其中SCI论文近50篇。
主要研究方向：
（1）中药药性与功效科学内涵研究。
（2）中药药效成分及作用机理解析。
（3）中药大健康产品组方设计与优化。
项目课题：
目前主持的主要科研课题：
（1）国家自然科学基金课题-基于系统中药学的丹参中药功效标志物发现研究；
（2）教育部新冠肺炎防控应急专项；
（3）北京中医药大学重点攻关项目-基于核心功效Q-marker的药材-饮片-提取物-成药的质量传递过程研究。
代表性论文：
1. Qiao L, Liu K, Ren Y, Liu Y, Xu Z, Wang S, Zhang Y. Scutellaria baicalensis ameliorates allergic airway inflammation through agonism and transcriptional regulation of TAS2Rs. J Ethnopharmacol. 2025 Jan 30;337(Pt 2):118881.Q1
2. Wang Z, Huo M, Qiao L, Qiao Y, Zhang Y. SYSTCM: A systemic web platform for objective identification of pharmacological effects based on interplay of "traditional Chinese Medicine-components-targets". Comput Biol Med. 2024 Sep;179:108878.Q1
3. Li B, Zheng L, Yuan A, Ren Y, Xu Z, Liu Y, Tian J, Yu B, Shi X, Qiao L, Zhang Y. Mechanism analysis of essential oil from Radix Bupleuri for the treatment of asthma through regulation of ectopic olfactory receptor. J Ethnopharmacol. 2024 Nov 15;334:118592.Q1
4. Li B, Liu C, Shu Z, et al. Disease Evolution-based Specificity Target Discovery (DESTD) by analyzing Jiawei-Maxing-shigan Decoctions against COVID-19. European Journal of Integrative Medicine. 2024 SEP;70:102386.
5. Yuan A, Liu C, Feng W, Li B, Zheng L, Tian J, Yu B, Zhang Y. Integrating Network Pharmacology, Quantitative Metabolic Network Analysis, In Vitro Experiments, and Molecular Dynamics to Explore the Mechanism of Angelica Sinensis for Regulating Bone Metabolism. Comb Chem High Throughput Screen. 2024 May 3.
6. Zheng L, Li B, Yuan A, Bi S, Puscher H, Liu C, Qiao L, Qiao Y, Wang S, Zhang Y. TFEB activator tanshinone IIA and derivatives derived from Salvia miltiorrhiza Bge. Attenuate hepatic steatosis and insulin resistance. J Ethnopharmacol. 2024 Dec 5;335:118662.Q1
7. Bi SJ, Yuan AL, Chen ZJ, Ren Y, Liu KY, Liu CQ, Xu ZZ, Wang ZW, Zhang YL. Quantitative predictive model for screening optimal processing methods of Polygonati rhizoma. J Asian Nat Prod Res. 2024 Aug 16:1-19.
8. Bi S, Xu Z, Wang Z, Liu Y, Yu B, Tian J, Liu C, Qiao L, Zhang Y. Polydatin from Polygoni Cuspidati Rhizoma et Radix regulates glucolipid metabolism in the liver of diabetic rats: Multiscale analysis of network pharmacology and multiomics. Phytomedicine. 2024 Aug 26;134:155992.Q1
9. Zhang J, Ren Y, Liu Y, Wang Z, Li Y, Li C, Chang H, Zhang Y. A systematic strategy for investigating the pharmacological effects and mechanism of traditional Chinese medicinal formula: Guilin Xiguashuang as a case. Fundam Clin Pharmacol. 2024 Apr;38(2):238-251.
10. Bi S, Liu Y, Lv T, Ren Y, Liu K, Liu C, Zhang Y. Preliminary exploration of method for screening efficacy markers compatibility in TCM prescriptions based on Q-markers: Anti-inflammatory activity of Dachaihu decoction as an example. J Ethnopharmacol. 2023 Aug 10;312:116539.Q1
11. Ren Y, Wu Q, Liu C, Zhang J, Wang Z, Li Y, Zhang Y. Discovery of a traditional Chinese herbal combination for the treatment of atopic dermatitis: saposhnikoviae radix, astragali radix and cnidium monnieri. Arch Dermatol Res. 2023 Sep;315(7):1953-1970.
12. Liu K, Chen X, Ren Y, Liu C, Lv T, Liu Y, Zhang Y. Multi-target-based polypharmacology prediction (mTPP): An approach using virtual screening and machine learning for multi-target drug discovery. Chem Biol Interact. 2022 Dec 1;368:110239.Q1
13. Liu K, Chen X, Ren Y, Liu C, Yuan A, Zheng L, Li B, Zhang Y. Identification of a novel farnesoid X receptor agonist, kaempferol-7-O-rhamnoside, a compound ameliorating drug-induced liver injury based on virtual screening and in vitro validation. Toxicol Appl Pharmacol. 2022 Nov 1;454:116251.
14. Liu C, Ren Y, Sui X, Liu K, Zhang J, Wang Z, Li Y, Zhang Y. Integrating network pharmacology, transcriptomics, and molecular simulation to reveal the mechanism of tert-butylhydroquinone for treating diabetic retinopathy. Eur J Pharmacol. 2022 Sep 15;931:175215.Q1
15. 马婧,霍晓乾,陈茜,朱卫星,姚美村,乔延江,张燕玲.基于Mpro和PLP筛选潜在抗新型冠状病毒中药研究[J].中国中药杂志,2020,45(06):1219-1224.（2022年度F5000论文）
16. 任越,姚美村,霍晓乾,谷宇,朱卫星,乔延江,张燕玲.抗新型冠状病毒方剂基于花生四烯酸代谢通路防治“细胞因子风暴”的研究[J].中国中药杂志,2020,45(06):1225-1231.（2022年度F5000论文）
联系方式：
通讯地址：北京市房山区阳光南大街北京中医药大学中药学院C座
邮政编码：102400
E-mail: zhangyanling@bucm.edu.cn