乔连生，北京中医药大学讲师，清华大学生物学博士，北京中医药大学中药学博士后。入选北京市科协青年人才托举工程（2025），国家资助博士后研究人员计划（B档，2023）。主要聚焦信息科技与生命科学融合（ITBT）驱动的中药作用机理解析与中药新药研发。在国内外学术期刊发表论文51篇，以第一/通讯作者在Signal Transduct Target Ther、J Adv Res等期刊上发表学术论文19篇（SCI论文11篇，EI论文1篇）。主持中国博士后科学基金面上资助，北京市自然科学基金青年项目各1项。授权发明专利3项、软件著作权2项。

 

主要研究方向：

1、ITBT驱动的中药功效物质与作用机制解析

2、ITBT驱动的中药设计与优化

 

主持在研课题：

北京市自然科学基金青年项目-基于靶向转录组解析左归丸通过HIF1A-CA9改善肾纤维化的药效物质和机制研究

 

代表性论文：

1、Qiao L, Huang W, Zhang X, Guo H, Wang D, Feng Q, Jin R, Xie L, Li W, Cheng J. Evaluation of the immunomodulatory effects of anti-COVID-19 TCM formulae by multiple virus-related pathways. Signal Transduct Target Ther. 2021 Feb 4;6(1):50.

2、Qiao L, Huo X, Huang W, Wang Z, Ren Y, Liu Y, Li Q, Zhang Y. Advances in high-throughput drug screening based on pharmacotranscriptomics. J Adv Res. 2025 Sep 11:S2090-1232(25)00689-7.

3、Qiao L, Liu K, Ren Y, Liu Y, Xu Z, Wang S, Zhang Y. Scutellaria baicalensis ameliorates allergic airway inflammation through agonism and transcriptional regulation of TAS2Rs. J Ethnopharmacol. 2025 Jan 30;337(Pt 2):118881.

4、Li B, Zheng L, Yuan A, Ren Y, Xu Z, Liu Y, Tian J, Yu B, Shi X, Qiao L, Zhang Y. Mechanism analysis of essential oil from Radix Bupleuri for the treatment of asthma through regulation of ectopic olfactory receptor. J Ethnopharmacol. 2024 Nov 15;334:118592.

5、Qiao L, Zhao X, Yuan A, Liu C, Wang Z, Huo X, Bi S, Tian J, Yu B, Lin Z, Zhang Y, Zhang J. Mechanism Analysis of Zuogui and Yougui Pills on Diabetic Nephropathy Through Transcriptional Regulatory Networks of HIF1A and PPARA. Food Sci Nutr. 2025 May 23;13(6):e70317.

6、Li B, Qiao L, Zhang J, Xiao Q, Liu J, Zhang B, Liu H. Natural 7,8-secolignans from Schisandra sphenanthera fruit potently inhibit SARS-CoV-2 3CLpro and inflammation. J Tradit Complement Med. 2024 Jan 16;14(5):501-509.

7、Qiao L, Li B, Chen Y, Li L, Chen X, Wang L, Lu F, Luo G, Li G, Zhang Y. Discovery of Anti-Hypertensive Oligopeptides from Adlay Based on In Silico Proteolysis and Virtual Screening. Int J Mol Sci. 2016 Dec 14;17(12):2099.

8、Qiao L, Zhang X, Jiang L, Zhang Y, Li G. Identification of potential ACAT-2 selective inhibitors using pharmacophore, SVM and SVR from Chinese herbs. Mol Divers. 2016 Nov;20(4):933-944.

9、Qiao L, He Y, Huo X , Jiang L, Chen Y, Chen X, Zhang Y, Li G. Construction and Evaluation of Merged Pharmacophore Based on Peroxisome Proliferator Receptor-Alpha Agonists.Chinese Journal of Chemical Physics, 2016, 29:508-516.

10、乔连生,李军,谢兰,张振鹏,常玉俊,黄文婷,郭弘妍,曹宏梅,解紫从,闫迪,张智,王阶,程京.基于靶向转录组、专家经验和人工智能研发守正创新中药的路径探索——以治疗慢性心力衰竭的中药新药研发为例.中医杂志,2023,64(03):217-224.

 

通讯地址：北京市房山区良乡大学城北京中医药大学中药学院

邮政编码：102488

E-mail：qiaoliansheng@bucm.edu.cn